Aging

• Accelerated aging processes 
• Segmental progeria disorders 
• Down's syndrome

Heart and Cardiovascular Disease

• Atherosclerosis 
• Adriamycin cardiotoxicity 
• Alcohol cardiomyopathy 

Gastrointestinal Tract

• Inflammatory & immune injury 
• Diabetes 
• Pancreatitis 
• Halogenated hydrocarbon liver injury 

Eye

• Cataractogenesis 
• Degenerative retinal damage 
• Macular degeneration 

Kidney

• Autoimmune nephrotic syndromes 
• Heavy metal nephrotoxicity 

Skin

• Solar radiation 
• Thermal injury 
• Porphyria 

Nervous System Disorders

• Hyperbaric oxygen 
• Parkinson's disease 
• Neuronal ceroid lipofuscinoses 
• Alzheimer's disease 
• Muscular dystrophy 
• Multiple sclerosis 

Lung

• Lung cancer (cigarette smoke) 
• Emphysema
• Bronchopulmonary dysphasia 
• Asbestos carcinogenicity 

Red Blood Cells

• Malaria ú Sickle cell anemia 
• Fanconi's anemia 
• Hemolytic anemia of prematurity 

Iron Overload

• Idiopathic hemochromatosis 
• Dietary iron overload 
• Thalassemia 

Inflammatory-Immune injury

• Glomerulonephritis 
• Autoimmune disease 
• Rheumatoid arthritis

Ischemia Reflow States

• Stroke 
• Myocardial infarction 

Liver

• Alcohol-induced pathology 
• Alcohol-induced iron overload injury
• Hepatitis B

Other Oxidative Stress Disorders

• Radiation-induced injuries (accidental and radiotherapy)
• General low-grade inflammatory disorders
• Inflamed rheumatoid joints